Endocannabinoids – An Interesting Graphic

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I found this very useful endocannabinoids graphic on LinkedIn:


This picture graphicly depicts the synthesis of the endocannabinoids 2-AG and AEA in the cellular lipid bilayer. They are made from ethanolamine, arachidonic acid and glycerol. Most every cell has the machinery to produce endocannabinoids, since the precursor molecules are present in all lipid bilayers.

This production of neurotransmitters in the cell membrane using membrane constituents is rather unique to the endocannabinoids. Remember, these are the molecules that plant-based cannabinoids mimic to produce their effects. Notice how many carbons and hydrogens there are in both plant-based and endogenous cannabinoids. This makes them fat soluble, and the receptors have fatty regions that attract the endogenous and plant-based cannabinoids. 

The endocannabinoid system is fascinating, and we look forward to further research.  

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